Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

Mason A. Israel, Shauna H. Yuan, Cedric Bardy, Sol M. Reyna, Yangling Mu, Cheryl Herrera, Michael P. Hefferan, Sebastiaan Van Gorp, Kristopher L. Nazor, Francesca S. Boscolo, Christian T. Carson, Louise C. Laurent, Martin Marsala, Fred H. Gage, Anne M. Remes, Edward H. Koo and Lawrence S. B. Goldstein ()
Additional contact information
Mason A. Israel: University of California, San Diego, La Jolla, California 92093, USA
Shauna H. Yuan: University of California, San Diego, La Jolla, California 92093, USA
Cedric Bardy: The Salk Institute for Biological Studies
Sol M. Reyna: University of California, San Diego, La Jolla, California 92093, USA
Yangling Mu: The Salk Institute for Biological Studies
Cheryl Herrera: University of California, San Diego, La Jolla, California 92093, USA
Michael P. Hefferan: University of California, San Diego, La Jolla, California 92093, USA
Sebastiaan Van Gorp: Maastricht University Medical Center
Kristopher L. Nazor: The Scripps Research Institute
Francesca S. Boscolo: University of California, San Diego, La Jolla, California 92093, USA
Christian T. Carson: BD Biosciences
Louise C. Laurent: University of California, San Diego, La Jolla, California 92093, USA
Martin Marsala: University of California, San Diego, La Jolla, California 92093, USA
Fred H. Gage: The Salk Institute for Biological Studies
Anne M. Remes: Neurology and Clinical Research Center, University of Oulu, Oulu FIN-90015, Finland
Edward H. Koo: University of California, San Diego, La Jolla, California, USA
Lawrence S. B. Goldstein: University of California, San Diego, La Jolla, California 92093, USA

Nature, 2012, vol. 482, issue 7384, 216-220

Abstract: Induced pluripotent stem cells are shown to be useful for studying phenotypes relevant to familial and sporadic Alzheimer’s disease, even though it can take decades for the disease to manifest in patients.

Date: 2012
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DOI: 10.1038/nature10821

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