Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

Jeremy Schwartzentruber, Andrey Korshunov, Xiao-Yang Liu, David T. W. Jones, Elke Pfaff, Karine Jacob, Dominik Sturm, Adam M. Fontebasso, Dong-Anh Khuong Quang, Martje Tönjes, Volker Hovestadt, Steffen Albrecht, Marcel Kool, Andre Nantel, Carolin Konermann, Anders Lindroth, Natalie Jäger, Tobias Rausch, Marina Ryzhova, Jan O. Korbel, Thomas Hielscher, Peter Hauser, Miklos Garami, Almos Klekner, Laszlo Bognar, Martin Ebinger, Martin U. Schuhmann, Wolfram Scheurlen, Arnulf Pekrun, Michael C. Frühwald, Wolfgang Roggendorf, Christoph Kramm, Matthias Dürken, Jeffrey Atkinson, Pierre Lepage, Alexandre Montpetit, Magdalena Zakrzewska, Krzystof Zakrzewski, Pawel P. Liberski, Zhifeng Dong, Peter Siegel, Andreas E. Kulozik, Marc Zapatka, Abhijit Guha, David Malkin, Jörg Felsberg, Guido Reifenberger, Andreas von Deimling, Koichi Ichimura, V. Peter Collins, Hendrik Witt, Till Milde, Olaf Witt, Cindy Zhang, Pedro Castelo-Branco, Peter Lichter, Damien Faury, Uri Tabori, Christoph Plass, Jacek Majewski (), Stefan M. Pfister () and Nada Jabado ()
Additional contact information
Jeremy Schwartzentruber: McGill University and Genome Quebec Innovation Centre
Andrey Korshunov: Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Xiao-Yang Liu: McGill University, Montreal, H3Z 2Z3, Canada
David T. W. Jones: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Elke Pfaff: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Karine Jacob: McGill University, Montreal, H3Z 2Z3, Canada
Dominik Sturm: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Adam M. Fontebasso: McGill University, Montreal, H3Z 2Z3, Canada
Dong-Anh Khuong Quang: McGill University, Montreal, H3Z 2Z3, Canada
Martje Tönjes: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Volker Hovestadt: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Steffen Albrecht: Montreal Children’s Hospital, McGill University Health Center, Montreal, Quebec H3H 1P3, Canada
Marcel Kool: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Andre Nantel: Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec H4P 2R2, Canada
Carolin Konermann: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Anders Lindroth: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Natalie Jäger: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Tobias Rausch: European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany
Marina Ryzhova: Burdenko Neurosurgical Institute, 125047 Moscow, Russia
Jan O. Korbel: European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany
Thomas Hielscher: German Cancer Research Center (DKFZ)
Peter Hauser: Semmelweis University
Miklos Garami: Semmelweis University
Almos Klekner: Medical and Health Science Center, University of Debrecen
Laszlo Bognar: Medical and Health Science Center, University of Debrecen
Martin Ebinger: Children’s University Hospital, 72076 Tübingen, Germany
Martin U. Schuhmann: University Hospital, 72076 Tübingen, Germany
Wolfram Scheurlen: Cnopfsche Kinderklinik, Nuremberg Children’s Hospital, 90419 Nuremberg, Germany
Arnulf Pekrun: Prof. Hess Children’s Hospital, 28177 Bremen, Germany
Michael C. Frühwald: Klinikum Augsburg, Augsburg Children’s Hospital, 86156 Augsburg, Germany
Wolfgang Roggendorf: Institute of Pathology, University of Würzburg, 97080 Würzburg, Germany
Christoph Kramm: University Children’s Hospital, 06097 Halle, Germany
Matthias Dürken: University Children’s Hospital, 68167 Mannheim, Germany
Jeffrey Atkinson: Montreal Children’s Hospital, McGill University Health Centre, Montreal, Quebec H3H 1P3, Canada
Pierre Lepage: McGill University and Genome Quebec Innovation Centre
Alexandre Montpetit: McGill University and Genome Quebec Innovation Centre
Magdalena Zakrzewska: Medical University of Lodz, 92-216 Poland
Krzystof Zakrzewski: Polish Mother’s Memorial Hospital Research Institute, Lodz, 93-338 Poland
Pawel P. Liberski: Medical University of Lodz, 92-216 Poland
Zhifeng Dong: Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 1A3, Canada
Peter Siegel: Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 1A3, Canada
Andreas E. Kulozik: Hematology and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany
Marc Zapatka: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Abhijit Guha: The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario M5G1X8, Canada
David Malkin: The Hospital for Sick Children, University of Toronto, Toronto, Ontario M5G 1X8, Canada
Jörg Felsberg: Heinrich-Heine-University, 40225 Düsseldorf, Germany
Guido Reifenberger: Heinrich-Heine-University, 40225 Düsseldorf, Germany
Andreas von Deimling: Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Koichi Ichimura: University of Cambridge
V. Peter Collins: University of Cambridge
Hendrik Witt: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Till Milde: Hematology and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany
Olaf Witt: Hematology and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany
Cindy Zhang: The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario M5G1X8, Canada
Pedro Castelo-Branco: The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario M5G1X8, Canada
Peter Lichter: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Damien Faury: McGill University, Montreal, H3Z 2Z3, Canada
Uri Tabori: The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario M5G1X8, Canada
Christoph Plass: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Jacek Majewski: McGill University, Montreal, H3Z 2Z3, Canada
Stefan M. Pfister: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Nada Jabado: McGill University, Montreal, H3Z 2Z3, Canada

Nature, 2012, vol. 482, issue 7384, 226-231

Abstract: Recurrent histone mutations are linked to paediatric glioblastoma multiforme, an aggressive type of brain tumour.

Date: 2012
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Citations: View citations in EconPapers (6)

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DOI: 10.1038/nature10833

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