Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion

Teresa L. M. Thurston, Michal P. Wandel, Natalia von Muhlinen, Ágnes Foeglein and Felix Randow ()
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Teresa L. M. Thurston: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Michal P. Wandel: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Natalia von Muhlinen: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Ágnes Foeglein: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Felix Randow: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK

Nature, 2012, vol. 482, issue 7385, 414-418

Abstract: Galectin 8, a cytosolic lectin, is shown to function as a danger receptor that detects damaged vesicles and protects cells from bacterial infection by inducing autophagy.

Date: 2012
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DOI: 10.1038/nature10744

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