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Extrathymically generated regulatory T cells control mucosal TH2 inflammation

Steven Z. Josefowicz, Rachel E. Niec, Hye Young Kim, Piper Treuting, Takatoshi Chinen, Ye Zheng, Dale T. Umetsu and Alexander Y. Rudensky ()
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Steven Z. Josefowicz: Howard Hughes Medical Institute and Immunology Program, Sloan Kettering Institute
Rachel E. Niec: Howard Hughes Medical Institute and Immunology Program, Sloan Kettering Institute
Hye Young Kim: Children’s Hospital, Harvard Medical School
Piper Treuting: and Histology and Imaging Core, School of Medicine, University of Washington
Takatoshi Chinen: Howard Hughes Medical Institute and Immunology Program, Sloan Kettering Institute
Ye Zheng: Nomis Foundation Laboratories for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies
Dale T. Umetsu: Children’s Hospital, Harvard Medical School
Alexander Y. Rudensky: Howard Hughes Medical Institute and Immunology Program, Sloan Kettering Institute

Nature, 2012, vol. 482, issue 7385, 395-399

Abstract: Selective impairment of peripheral regulatory T-cell differentiation is found to result in spontaneous allergic TH2-type inflammation in the intestine and lungs, demonstrating the functional heterogeneity of regulatory T cells generated in the thymus and extrathymically in controlling immune mediated inflammation and disease.

Date: 2012
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DOI: 10.1038/nature10772

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