Extrathymically generated regulatory T cells control mucosal TH2 inflammation

Steven Z. Josefowicz, Rachel E. Niec, Hye Young Kim, Piper Treuting, Takatoshi Chinen, Ye Zheng, Dale T. Umetsu and Alexander Y. Rudensky ()
Additional contact information
Steven Z. Josefowicz: Howard Hughes Medical Institute and Immunology Program, Sloan Kettering Institute
Rachel E. Niec: Howard Hughes Medical Institute and Immunology Program, Sloan Kettering Institute
Hye Young Kim: Children’s Hospital, Harvard Medical School
Piper Treuting: and Histology and Imaging Core, School of Medicine, University of Washington
Takatoshi Chinen: Howard Hughes Medical Institute and Immunology Program, Sloan Kettering Institute
Ye Zheng: Nomis Foundation Laboratories for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies
Dale T. Umetsu: Children’s Hospital, Harvard Medical School
Alexander Y. Rudensky: Howard Hughes Medical Institute and Immunology Program, Sloan Kettering Institute

Nature, 2012, vol. 482, issue 7385, 395-399

Abstract: Selective impairment of peripheral regulatory T-cell differentiation is found to result in spontaneous allergic TH2-type inflammation in the intestine and lungs, demonstrating the functional heterogeneity of regulatory T cells generated in the thymus and extrathymically in controlling immune mediated inflammation and disease.

Date: 2012
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DOI: 10.1038/nature10772

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