DNase I sensitivity QTLs are a major determinant of human expression variation

Jacob F. Degner, Athma A. Pai, Roger Pique-Regi, Jean-Baptiste Veyrieras, Daniel J. Gaffney, Joseph K. Pickrell, Sherryl De Leon, Katelyn Michelini, Noah Lewellen, Gregory E. Crawford, Matthew Stephens, Yoav Gilad () and Jonathan K. Pritchard ()
Additional contact information
Jacob F. Degner: University of Chicago, Chicago, Illinois 60637, USA
Athma A. Pai: University of Chicago, Chicago, Illinois 60637, USA
Roger Pique-Regi: University of Chicago, Chicago, Illinois 60637, USA
Jean-Baptiste Veyrieras: University of Chicago, Chicago, Illinois 60637, USA
Daniel J. Gaffney: University of Chicago, Chicago, Illinois 60637, USA
Joseph K. Pickrell: University of Chicago, Chicago, Illinois 60637, USA
Sherryl De Leon: Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA
Katelyn Michelini: Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA
Noah Lewellen: Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA
Gregory E. Crawford: Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27708, USA
Matthew Stephens: University of Chicago, Chicago, Illinois 60637, USA
Yoav Gilad: University of Chicago, Chicago, Illinois 60637, USA
Jonathan K. Pritchard: University of Chicago, Chicago, Illinois 60637, USA

Nature, 2012, vol. 482, issue 7385, 390-394

Abstract: In human lymphoblastoid cell lines, 8,902 loci were identified at which genetic variation is significantly associated with local DNase I sensitivity; these variants are responsible for a large fraction of expression quantitative trait loci.

Date: 2012
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DOI: 10.1038/nature10808

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