RNA-guided genetic silencing systems in bacteria and archaea

Blake Wiedenheft, Samuel H. Sternberg and Jennifer A. Doudna ()
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Blake Wiedenheft: Howard Hughes Medical Institute
Samuel H. Sternberg: University of California
Jennifer A. Doudna: Howard Hughes Medical Institute

Nature, 2012, vol. 482, issue 7385, 331-338

Abstract: Abstract Clustered regularly interspaced short palindromic repeat (CRISPR) are essential components of nucleic-acid-based adaptive immune systems that are widespread in bacteria and archaea. Similar to RNA interference (RNAi) pathways in eukaryotes, CRISPR-mediated immune systems rely on small RNAs for sequence-specific detection and silencing of foreign nucleic acids, including viruses and plasmids. However, the mechanism of RNA-based bacterial immunity is distinct from RNAi. Understanding how small RNAs are used to find and destroy foreign nucleic acids will provide new insights into the diverse mechanisms of RNA-controlled genetic silencing systems.

Date: 2012
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DOI: 10.1038/nature10886

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