The microcosmos of cancer

Amaia Lujambio and Scott W. Lowe ()
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Amaia Lujambio: Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center (MSKCC)
Scott W. Lowe: Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center (MSKCC)

Nature, 2012, vol. 482, issue 7385, 347-355

Abstract: Abstract The discovery of microRNAs (miRNAs) almost two decades ago established a new paradigm of gene regulation. During the past ten years these tiny non-coding RNAs have been linked to virtually all known physiological and pathological processes, including cancer. In the same way as certain key protein-coding genes, miRNAs can be deregulated in cancer, in which they can function as a group to mark differentiation states or individually as bona fide oncogenes or tumour suppressors. Importantly, miRNA biology can be harnessed experimentally to investigate cancer phenotypes or used therapeutically as a target for drugs or as the drug itself.

Date: 2012
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DOI: 10.1038/nature10888

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