DCC constrains tumour progression via its dependence receptor activity

Marie Castets, Laura Broutier, Yann Molin, Marie Brevet, Guillaume Chazot, Nicolas Gadot, Armelle Paquet, Laetitia Mazelin, Loraine Jarrosson-Wuilleme, Jean-Yves Scoazec, Agnès Bernet and Patrick Mehlen ()
Additional contact information
Marie Castets: Apoptosis, Cancer and Development Laboratory - Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon
Laura Broutier: Apoptosis, Cancer and Development Laboratory - Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon
Yann Molin: Apoptosis, Cancer and Development Laboratory - Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon
Marie Brevet: Endocrine Differentiation Laboratory, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon, Hospices Civils de Lyon, Hôpital Edouard Herriot
Guillaume Chazot: Apoptosis, Cancer and Development Laboratory - Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon
Nicolas Gadot: Endocrine Differentiation Laboratory, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon, Hospices Civils de Lyon, Hôpital Edouard Herriot
Armelle Paquet: Endocrine Differentiation Laboratory, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon, Hospices Civils de Lyon, Hôpital Edouard Herriot
Laetitia Mazelin: Apoptosis, Cancer and Development Laboratory - Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon
Loraine Jarrosson-Wuilleme: Apoptosis, Cancer and Development Laboratory - Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon
Jean-Yves Scoazec: Endocrine Differentiation Laboratory, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon, Hospices Civils de Lyon, Hôpital Edouard Herriot
Agnès Bernet: Apoptosis, Cancer and Development Laboratory - Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon
Patrick Mehlen: Apoptosis, Cancer and Development Laboratory - Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon

Nature, 2012, vol. 482, issue 7386, 534-537

Abstract: A mouse model is developed in which the pro-apoptotic activity of DCC is silenced and the mice are more prone to intestinal tumour progression, giving insight into the role of DCC in human colorectal cancer.

Date: 2012
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature10708 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:482:y:2012:i:7386:d:10.1038_nature10708

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature10708

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().