Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours

Paul Krimpenfort, Ji-Ying Song, Natalie Proost, John Zevenhoven, Jos Jonkers and Anton Berns ()
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Paul Krimpenfort: The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
Ji-Ying Song: The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
Natalie Proost: The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
John Zevenhoven: The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
Jos Jonkers: The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
Anton Berns: The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands

Nature, 2012, vol. 482, issue 7386, 538-541

Abstract: In a mouse model of mammary carcinoma, loss of deleted in colorectal cancer (DCC) promotes metastasis formation, and in cell cultures derived from p53-deficient mouse mammary tumours DCC expression controls netrin-1-dependent cell survival, supporting the function of DCC as a context-dependent tumour suppressor that limits survival of disseminated tumour cells.

Date: 2012
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DOI: 10.1038/nature10790

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