Clonal selection drives genetic divergence of metastatic medulloblastoma

Xiaochong Wu, Paul A. Northcott, Adrian Dubuc, Adam J. Dupuy, David J. H. Shih, Hendrik Witt, Sidney Croul, Eric Bouffet, Daniel W. Fults, Charles G. Eberhart, Livia Garzia, Timothy Van Meter, David Zagzag, Nada Jabado, Jeremy Schwartzentruber, Jacek Majewski, Todd E. Scheetz, Stefan M. Pfister, Andrey Korshunov, Xiao-Nan Li, Stephen W. Scherer, Yoon-Jae Cho, Keiko Akagi, Tobey J. MacDonald, Jan Koster, Martin G. McCabe, Aaron L. Sarver, V. Peter Collins, William A. Weiss, David A. Largaespada, Lara S. Collier and Michael D. Taylor ()
Additional contact information
Xiaochong Wu: Arthur and Sonia Labatt Brain Tumour Research Center, and Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Paul A. Northcott: Arthur and Sonia Labatt Brain Tumour Research Center, and Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Adrian Dubuc: Arthur and Sonia Labatt Brain Tumour Research Center, and Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Adam J. Dupuy: Molecular & Cellular Biology Program, The University of Iowa
David J. H. Shih: Arthur and Sonia Labatt Brain Tumour Research Center, and Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Hendrik Witt: German Cancer Research Center (DKFZ), Hematology and Immunology, University Hospital Heidelberg, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Sidney Croul: University Health Network Pathology, Arthur and Sonia Labatt Brain Tumour Research Centre, University of Toronto, Toronto, Ontario M5S 1A1, Canada
Eric Bouffet: Brain Tumour Program, Haematology and Oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Daniel W. Fults: University of Utah School of Medicine
Charles G. Eberhart: Johns Hopkins University
Livia Garzia: Arthur and Sonia Labatt Brain Tumour Research Center, and Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Timothy Van Meter: Virginia Commonwealth University
David Zagzag: New York University School of Medicine
Nada Jabado: McGill University, Montreal H3Z 2Z3, Quebec, Canada
Jeremy Schwartzentruber: McGill University and Genome Quebec Innovation Centre, Montreal, Quebec H3A 0G1, Canada
Jacek Majewski: McGill University, Montreal H3Z 2Z3, Quebec, Canada
Todd E. Scheetz: Molecular & Cellular Biology Program, The University of Iowa
Stefan M. Pfister: German Cancer Research Center (DKFZ), Hematology and Immunology, University Hospital Heidelberg, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Andrey Korshunov: University of Heidelberg, Im Neuenheimer Feld 220/221, 69120 Heidelberg, Germany
Xiao-Nan Li: Brain Tumor Program, Texas Children’s Cancer Center, Baylor College of Medicine
Stephen W. Scherer: Program in Genetics and Genomic Biology and The Centre for Applied Genomics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario M5S 1A1, Canada
Yoon-Jae Cho: Stanford University School of Medicine
Keiko Akagi: Immunology and Medical Genetics, The Ohio State University Comprehensive Cancer Center
Tobey J. MacDonald: Pediatric Neuro-Oncology Program, Emory University School of Medicine
Jan Koster: Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
Martin G. McCabe: School of Cancer and Enabling Sciences, University of Manchester, Manchester M20 4BX, UK
Aaron L. Sarver: Masonic Cancer Center, University of Minnesota
V. Peter Collins: University of Cambridge, Cambridge CB2 1QP, UK
William A. Weiss: Pediatrics and Neurological Surgery, University of California
David A. Largaespada: Masonic Cancer Center, University of Minnesota
Lara S. Collier: School of Pharmacology, University of Wisconsin
Michael D. Taylor: Arthur and Sonia Labatt Brain Tumour Research Center, and Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario M5G 1X8, Canada

Nature, 2012, vol. 482, issue 7386, 529-533

Abstract: In a mouse model and in human medulloblastoma patients, the metastases in an individual have similar genomic alterations and DNA methylation patterns, but these patterns are highly divergent from those of the primary tumour, indicating that therapies will need to be tailored to fit the molecular alterations present in the primary tumour and/or the metastases.

Date: 2012
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DOI: 10.1038/nature10825

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