Maintenance of muscle stem-cell quiescence by microRNA-489

Tom H. Cheung, Navaline L. Quach, Gregory W. Charville, Ling Liu, Lidia Park, Abdolhossein Edalati, Bryan Yoo, Phuong Hoang and Thomas A. Rando ()
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Tom H. Cheung: Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
Navaline L. Quach: Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
Gregory W. Charville: Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
Ling Liu: Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
Lidia Park: Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
Abdolhossein Edalati: Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
Bryan Yoo: Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
Phuong Hoang: Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
Thomas A. Rando: Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine

Nature, 2012, vol. 482, issue 7386, 524-528

Abstract: Adult muscle stem cells are used as a model system to show that the microRNA pathway, and specifically miR-489, is essential for the maintenance of the quiescent state of an adult stem-cell population by suppressing a key proliferation factor, Dek.

Date: 2012
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DOI: 10.1038/nature10834

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