Structural and functional conservation of key domains in InsP3 and ryanodine receptors

Min-Duk Seo, Saroj Velamakanni, Noboru Ishiyama, Peter B. Stathopulos, Ana M. Rossi, Samir A. Khan, Philippa Dale, Congmin Li, James B. Ames, Mitsuhiko Ikura () and Colin W. Taylor ()
Additional contact information
Min-Duk Seo: University of Toronto, Ontario M5G 1L7, Canada
Saroj Velamakanni: University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK
Noboru Ishiyama: University of Toronto, Ontario M5G 1L7, Canada
Peter B. Stathopulos: University of Toronto, Ontario M5G 1L7, Canada
Ana M. Rossi: University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK
Samir A. Khan: University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK
Philippa Dale: University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK
Congmin Li: University of California
James B. Ames: University of California
Mitsuhiko Ikura: University of Toronto, Ontario M5G 1L7, Canada
Colin W. Taylor: University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK

Nature, 2012, vol. 483, issue 7387, 108-112

Abstract: Structures of the amino-terminal region of inositol-1,4,5-trisphosphate receptor 1 with and without InsP3 bound reveal two discrete interfaces between the InsP3-binding core and suppressor domain that are similar to and functionally interchangeable with those in the equivalent domains of ryanodine receptor 1.

Date: 2012
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DOI: 10.1038/nature10751

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