Strict evolutionary conservation followed rapid gene loss on human and rhesus Y chromosomes

Jennifer F. Hughes (), Helen Skaletsky, Laura G. Brown, Tatyana Pyntikova, Tina Graves, Robert S. Fulton, Shannon Dugan, Yan Ding, Christian J. Buhay, Colin Kremitzki, Qiaoyan Wang, Hua Shen, Michael Holder, Donna Villasana, Lynne V. Nazareth, Andrew Cree, Laura Courtney, Joelle Veizer, Holland Kotkiewicz, Ting-Jan Cho, Natalia Koutseva, Steve Rozen, Donna M. Muzny, Wesley C. Warren, Richard A. Gibbs, Richard K. Wilson and David C. Page
Additional contact information
Jennifer F. Hughes: Howard Hughes Medical Institute, Massachusetts Institute of Technology, 9 Cambridge Center
Helen Skaletsky: Howard Hughes Medical Institute, Massachusetts Institute of Technology, 9 Cambridge Center
Laura G. Brown: Howard Hughes Medical Institute, Massachusetts Institute of Technology, 9 Cambridge Center
Tatyana Pyntikova: Howard Hughes Medical Institute, Massachusetts Institute of Technology, 9 Cambridge Center
Tina Graves: The Genome Institute, Washington University School of Medicine, 4444 Forest Park Boulevard, St. Louis, Missouri 63108, USA
Robert S. Fulton: The Genome Institute, Washington University School of Medicine, 4444 Forest Park Boulevard, St. Louis, Missouri 63108, USA
Shannon Dugan: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Yan Ding: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Christian J. Buhay: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Colin Kremitzki: The Genome Institute, Washington University School of Medicine, 4444 Forest Park Boulevard, St. Louis, Missouri 63108, USA
Qiaoyan Wang: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Hua Shen: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Michael Holder: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Donna Villasana: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Lynne V. Nazareth: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Andrew Cree: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Laura Courtney: The Genome Institute, Washington University School of Medicine, 4444 Forest Park Boulevard, St. Louis, Missouri 63108, USA
Joelle Veizer: The Genome Institute, Washington University School of Medicine, 4444 Forest Park Boulevard, St. Louis, Missouri 63108, USA
Holland Kotkiewicz: The Genome Institute, Washington University School of Medicine, 4444 Forest Park Boulevard, St. Louis, Missouri 63108, USA
Ting-Jan Cho: Howard Hughes Medical Institute, Massachusetts Institute of Technology, 9 Cambridge Center
Natalia Koutseva: Howard Hughes Medical Institute, Massachusetts Institute of Technology, 9 Cambridge Center
Steve Rozen: Howard Hughes Medical Institute, Massachusetts Institute of Technology, 9 Cambridge Center
Donna M. Muzny: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Wesley C. Warren: The Genome Institute, Washington University School of Medicine, 4444 Forest Park Boulevard, St. Louis, Missouri 63108, USA
Richard A. Gibbs: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Richard K. Wilson: The Genome Institute, Washington University School of Medicine, 4444 Forest Park Boulevard, St. Louis, Missouri 63108, USA
David C. Page: Howard Hughes Medical Institute, Massachusetts Institute of Technology, 9 Cambridge Center

Nature, 2012, vol. 483, issue 7387, 82-86

Abstract: The male-specific region of rhesus macaque and human Y chromosome (MSY) are sequenced and compared to the human MSY, showing that during the last 25 million years MSY gene loss in the rhesus and human lineages was limited to the youngest stratum (stratum 5), whereas gene loss in the older strata ceased more than 25 million years ago.

Date: 2012
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DOI: 10.1038/nature10843

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