Circadian rhythms govern cardiac repolarization and arrhythmogenesis

Darwin Jeyaraj (), Saptarsi M. Haldar, Xiaoping Wan, Mark D. McCauley, Jürgen A. Ripperger, Kun Hu, Yuan Lu, Betty L. Eapen, Nikunj Sharma, Eckhard Ficker, Michael J. Cutler, James Gulick, Atsushi Sanbe, Jeffrey Robbins, Sophie Demolombe, Roman V. Kondratov, Steven A. Shea, Urs Albrecht, Xander H. T. Wehrens, David S. Rosenbaum and Mukesh K. Jain ()
Additional contact information
Darwin Jeyaraj: Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Case Western Reserve University School of Medicine
Saptarsi M. Haldar: Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Case Western Reserve University School of Medicine
Xiaoping Wan: Heart and Vascular Research Center, MetroHealth campus of Case Western Reserve University
Mark D. McCauley: Baylor College of Medicine
Jürgen A. Ripperger: University of Fribourg, CH-1700 Fribourg, Switzerland
Kun Hu: Brigham and Women’s Hospital and Harvard Medical School
Yuan Lu: Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Case Western Reserve University School of Medicine
Betty L. Eapen: Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Case Western Reserve University School of Medicine
Nikunj Sharma: Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Case Western Reserve University School of Medicine
Eckhard Ficker: Heart and Vascular Research Center, MetroHealth campus of Case Western Reserve University
Michael J. Cutler: Heart and Vascular Research Center, MetroHealth campus of Case Western Reserve University
James Gulick: Cincinnati Children’s Hospital Medical Center
Atsushi Sanbe: Cincinnati Children’s Hospital Medical Center
Jeffrey Robbins: Cincinnati Children’s Hospital Medical Center
Sophie Demolombe: Institut de Pharmacologie Moléculaire et Cellulaire, UMR CNRS 6097, Université de Nice Sophia Antipolis
Roman V. Kondratov: Geological and Environmental Sciences, and Center for Gene Regulation in Health and Disease, Cleveland State University
Steven A. Shea: Brigham and Women’s Hospital and Harvard Medical School
Urs Albrecht: University of Fribourg, CH-1700 Fribourg, Switzerland
Xander H. T. Wehrens: Baylor College of Medicine
David S. Rosenbaum: Heart and Vascular Research Center, MetroHealth campus of Case Western Reserve University
Mukesh K. Jain: Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Case Western Reserve University School of Medicine

Nature, 2012, vol. 483, issue 7387, 96-99

Abstract: Circadian rhythmicity of cardiac ion-channel expression and of an index of myocardial repolarization is under the control of Klf15, a clock-dependent oscillator that is required for generating transient outward potassium current, and deficiencies or excesses of which cause loss of rhythmic variation in myocardial and abnormal repolarization, and an enhanced susceptibility to ventricular arrhythmias.

Date: 2012
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DOI: 10.1038/nature10852

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