The sirtuin SIRT6 regulates lifespan in male mice

Yariv Kanfi, Shoshana Naiman, Gail Amir, Victoria Peshti, Guy Zinman, Liat Nahum, Ziv Bar-Joseph and Haim Y. Cohen ()
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Yariv Kanfi: The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University
Shoshana Naiman: The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University
Gail Amir: Hadassah Medical Center and Hebrew University
Victoria Peshti: The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University
Guy Zinman: Lane Center for Computational Biology, School of Computer Science, Carnegie Mellon University
Liat Nahum: The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University
Ziv Bar-Joseph: Lane Center for Computational Biology, School of Computer Science, Carnegie Mellon University
Haim Y. Cohen: The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University

Nature, 2012, vol. 483, issue 7388, 218-221

Abstract: The role of sirtuins in longevity is controversial, and little is known about mammalian sirtuins; now, male mice that overexpress SIRT6 are shown to have a longer lifespan than wild-type mice, unlike their female counterparts.

Date: 2012
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DOI: 10.1038/nature10815

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