Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain

Douglas J. Cook, Lucy Teves and Michael Tymianski ()
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Douglas J. Cook: Toronto Western Hospital Research Institute, Toronto
Lucy Teves: Toronto Western Hospital Research Institute, Toronto
Michael Tymianski: Toronto Western Hospital Research Institute, Toronto

Nature, 2012, vol. 483, issue 7388, 213-217

Abstract: Tat-NR2B9c, a PSD-95 inhibitor, is shown to reduce stroke-induced behavioural and neuroanatomical deficits in cynomolgous macaques when administered in the presence of an ischemic penumbra, suggesting the potential of PSD-95 inhibition as a neuroprotectant strategy for clinical investigation.

Date: 2012
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DOI: 10.1038/nature10841

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