An epigenetic blockade of cognitive functions in the neurodegenerating brain

Johannes Gräff, Damien Rei, Ji-Song Guan, Wen-Yuan Wang, Jinsoo Seo, Krista M. Hennig, Thomas J. F. Nieland, Daniel M. Fass, Patricia F. Kao, Martin Kahn, Susan C. Su, Alireza Samiei, Nadine Joseph, Stephen J. Haggarty, Ivana Delalle and Li-Huei Tsai ()
Additional contact information
Johannes Gräff: Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Damien Rei: Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Ji-Song Guan: Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Wen-Yuan Wang: Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Jinsoo Seo: Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Krista M. Hennig: Stanley Center for Psychiatric Research, Broad Institute of Harvard University and Massachusetts Institute of Technology
Thomas J. F. Nieland: Stanley Center for Psychiatric Research, Broad Institute of Harvard University and Massachusetts Institute of Technology
Daniel M. Fass: Stanley Center for Psychiatric Research, Broad Institute of Harvard University and Massachusetts Institute of Technology
Patricia F. Kao: Boston University School of Medicine
Martin Kahn: Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Susan C. Su: Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Alireza Samiei: Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Nadine Joseph: Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Stephen J. Haggarty: Stanley Center for Psychiatric Research, Broad Institute of Harvard University and Massachusetts Institute of Technology
Ivana Delalle: Boston University School of Medicine
Li-Huei Tsai: Picower Institute for Learning and Memory, Massachusetts Institute of Technology

Nature, 2012, vol. 483, issue 7388, 222-226

Abstract: Histone deacetylase 2 is shown to suppress genes involved in cognitive function epigenetically, potentially opening the door to treatments for Alzheimer’s and other neurodegenerative diseases by developing HDAC2-selective inhibitors.

Date: 2012
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/nature10849 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:483:y:2012:i:7388:d:10.1038_nature10849

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature10849

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().