Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity

Xiaodong Jiang, Rachael A. Clark, Luzheng Liu, Amy J. Wagers, Robert C. Fuhlbrigge and Thomas S. Kupper
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Xiaodong Jiang: Brigham and Women’s Hospital, Harvard Medical School
Rachael A. Clark: Brigham and Women’s Hospital, Harvard Medical School
Luzheng Liu: Brigham and Women’s Hospital, Harvard Medical School
Amy J. Wagers: Harvard University, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Joslin Diabetes Center
Robert C. Fuhlbrigge: Brigham and Women’s Hospital, Harvard Medical School
Thomas S. Kupper: Brigham and Women’s Hospital, Harvard Medical School

Nature, 2012, vol. 483, issue 7388, 227-231

Abstract: Local skin infection is shown to generate long-lived T cells that reside throughout the skin and are potent effector cells, superior to circulating memory T cells in providing rapid long-term protection again cutaneous re-infection.

Date: 2012
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DOI: 10.1038/nature10851

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