Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

Atsuhiko Ichimura, Akira Hirasawa, Odile Poulain-Godefroy, Amélie Bonnefond, Takafumi Hara, Loïc Yengo, Ikuo Kimura, Audrey Leloire, Ning Liu, Keiko Iida, Hélène Choquet, Philippe Besnard, Cécile Lecoeur, Sidonie Vivequin, Kumiko Ayukawa, Masato Takeuchi, Kentaro Ozawa, Maithé Tauber, Claudio Maffeis, Anita Morandi, Raffaella Buzzetti, Paul Elliott, Anneli Pouta, Marjo-Riitta Jarvelin, Antje Körner, Wieland Kiess, Marie Pigeyre, Roberto Caiazzo, Wim Van Hul, Luc Van Gaal, Fritz Horber, Beverley Balkau, Claire Lévy-Marchal, Konstantinos Rouskas, Anastasia Kouvatsi, Johannes Hebebrand, Anke Hinney, Andre Scherag, François Pattou, David Meyre, Taka-aki Koshimizu, Isabelle Wolowczuk, Gozoh Tsujimoto () and Philippe Froguel ()
Additional contact information
Atsuhiko Ichimura: Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan
Akira Hirasawa: Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan
Odile Poulain-Godefroy: Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59000, France
Amélie Bonnefond: Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59000, France
Takafumi Hara: Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan
Loïc Yengo: Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59000, France
Ikuo Kimura: Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan
Audrey Leloire: Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59000, France
Ning Liu: Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan
Keiko Iida: Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan
Hélène Choquet: Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59000, France
Philippe Besnard: Institut National de la Santé et de la Recherche Médicale (Inserm)-UMR U866, Physiologie de la Nutrition, Bourgogne University, AgroSup Dijon, Dijon 21078, France
Cécile Lecoeur: Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59000, France
Sidonie Vivequin: Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59000, France
Kumiko Ayukawa: Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan
Masato Takeuchi: Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan
Kentaro Ozawa: Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan
Maithé Tauber: Inserm-U563, Children’s Hospital, Centre Hospitalier Universitaire, Toulouse 31000, France
Claudio Maffeis: Regional Centre for Juvenile Diabetes, Obesity and Clinical Nutrition, Verona 37134, Italy
Anita Morandi: Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59000, France
Raffaella Buzzetti: La Sapienza University, Rome 00161, Italy
Paul Elliott: Medical Research Council-HPA Centre for Environment and Health, School of Public Health, St Mary’s campus, Imperial College London, London W2 1PG, UK
Anneli Pouta: National Public Health Institute, Biocenter Oulu, University of Oulu, Oulu 90220, Finland
Marjo-Riitta Jarvelin: Medical Research Council-HPA Centre for Environment and Health, School of Public Health, St Mary’s campus, Imperial College London, London W2 1PG, UK
Antje Körner: Center for Pediatric Research, University of Leipzig, Leipzig 04317, Germany
Wieland Kiess: Center for Pediatric Research, University of Leipzig, Leipzig 04317, Germany
Marie Pigeyre: Inserm-U859, Lille Nord de France University, Lille 59000, France
Roberto Caiazzo: Inserm-U859, Lille Nord de France University, Lille 59000, France
Wim Van Hul: University of Antwerp, Antwerp 2610, Belgium
Luc Van Gaal: Antwerp University Hospital, Antwerp 2650, Belgium
Fritz Horber: Clinic Lindberg, Winterthur 8400, and University of Berne, Berne 3011, Switzerland
Beverley Balkau: Inserm-U780, Centre for research in Epidemiology and Population Health (CRESP), Villejuif 94800, France
Claire Lévy-Marchal: Inserm-U690, Robert Debré hospital, Paris 75935, France
Konstantinos Rouskas: Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59000, France
Anastasia Kouvatsi: Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki 541 24, Greece
Johannes Hebebrand: University of Duisburg-Essen, Essen 45147, Germany
Anke Hinney: University of Duisburg-Essen, Essen 45147, Germany
Andre Scherag: Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen 45122, Germany
François Pattou: Inserm-U859, Lille Nord de France University, Lille 59000, France
David Meyre: Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59000, France
Taka-aki Koshimizu: Jichi Medical University, Tochigi 329-0498, Japan
Isabelle Wolowczuk: Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59000, France
Gozoh Tsujimoto: Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan
Philippe Froguel: Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59000, France

Nature, 2012, vol. 483, issue 7389, 350-354

Abstract: Mice deficient in the lipid sensor GPR120 develop obesity, glucose intolerance and fatty liver when fed a high-fat diet, and a loss-of-function variant in the GPR120 gene strongly contributes to increased obesity in human.

Date: 2012
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DOI: 10.1038/nature10798

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