Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis

Kinya Hotta, Xi Chen, Robert S. Paton, Atsushi Minami, Hao Li, Kunchithapadam Swaminathan, Irimpan I. Mathews, Kenji Watanabe, Hideaki Oikawa, Kendall N. Houk and Chu-Young Kim ()
Additional contact information
Kinya Hotta: National University of Singapore, 14 Science Drive 4, 117543 Singapore
Xi Chen: National University of Singapore, 14 Science Drive 4, 117543 Singapore
Robert S. Paton: Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK
Atsushi Minami: Hokkaido University, Graduate School of Science, North 10 West 8, Sapporo 060-0810, Japan
Hao Li: National University of Singapore, 14 Science Drive 4, 117543 Singapore
Kunchithapadam Swaminathan: National University of Singapore, 14 Science Drive 4, 117543 Singapore
Irimpan I. Mathews: Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, 2575 Sand Hill Road MS 99, Menlo Park, California 95124, USA
Kenji Watanabe: University of Shizuoka, Graduate School of Pharmaceutical Sciences, 52-1 Yada, Suruga-ku, Shizuoka City, Shizuoka 422-8526, Japan
Hideaki Oikawa: Hokkaido University, Graduate School of Science, North 10 West 8, Sapporo 060-0810, Japan
Kendall N. Houk: University of California Los Angeles, 607 Charles E. Young Drive East, Box 951569, Los Angeles, California 90095-1569, USA
Chu-Young Kim: National University of Singapore, 14 Science Drive 4, 117543 Singapore

Nature, 2012, vol. 483, issue 7389, 355-358

Abstract: The X-ray crystal structure of the epoxide hydrolase Lsd19 in complex with its substrate and product analogue is determined, providing insight into a general mechanism of enzyme-catalysed formation of polyether natural products.

Date: 2012
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DOI: 10.1038/nature10865

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