On the difficulty of increasing dental complexity

Enni Harjunmaa, Aki Kallonen, Maria Voutilainen, Keijo Hämäläinen, Marja L. Mikkola and Jukka Jernvall ()
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Enni Harjunmaa: Developmental Biology Program, Institute of Biotechnology, University of Helsinki, P.O. Box 56, FIN-00014 Helsinki, Finland
Aki Kallonen: University of Helsinki, P.O. Box 64, FIN-00014 Helsinki, Finland
Maria Voutilainen: Developmental Biology Program, Institute of Biotechnology, University of Helsinki, P.O. Box 56, FIN-00014 Helsinki, Finland
Keijo Hämäläinen: University of Helsinki, P.O. Box 64, FIN-00014 Helsinki, Finland
Marja L. Mikkola: Developmental Biology Program, Institute of Biotechnology, University of Helsinki, P.O. Box 56, FIN-00014 Helsinki, Finland
Jukka Jernvall: Developmental Biology Program, Institute of Biotechnology, University of Helsinki, P.O. Box 56, FIN-00014 Helsinki, Finland

Nature, 2012, vol. 483, issue 7389, 324-327

Abstract: Activation of EDA and activin A signalling, and inhibition of SHH signalling pathways together increase the number of cusps on cultured mouse cheek teeth, showing that a substantial increase in complexity requires multiple changes in developmental regulation.

Date: 2012
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DOI: 10.1038/nature10876

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