Phase transitions in the assembly of multivalent signalling proteins

Pilong Li, Sudeep Banjade, Hui-Chun Cheng, Soyeon Kim, Baoyu Chen, Liang Guo, Marc Llaguno, Javoris V. Hollingsworth, David S. King, Salman F. Banani, Paul S. Russo, Qiu-Xing Jiang, B. Tracy Nixon and Michael K. Rosen ()
Additional contact information
Pilong Li: University of Texas Southwestern Medical Center
Sudeep Banjade: University of Texas Southwestern Medical Center
Hui-Chun Cheng: University of Texas Southwestern Medical Center
Soyeon Kim: University of Texas Southwestern Medical Center
Baoyu Chen: University of Texas Southwestern Medical Center
Liang Guo: BioCAT of IIT at the Advanced Photon Source, Argonne National Laboratory, 9700 South Cass Avenue
Marc Llaguno: University of Texas Southwestern Medical Center
Javoris V. Hollingsworth: Louisiana State University
David S. King: University of California
Salman F. Banani: University of Texas Southwestern Medical Center
Paul S. Russo: Louisiana State University
Qiu-Xing Jiang: University of Texas Southwestern Medical Center
B. Tracy Nixon: The Pennsylvania State University, University Park
Michael K. Rosen: University of Texas Southwestern Medical Center

Nature, 2012, vol. 483, issue 7389, 336-340

Abstract: The mechanisms by which the ångström-scale molecular properties of cells are translated to micrometre-scale macroscopic properties have not been well understood, but this study shows that when multivalent proteins interact with each other, they undergo a switch-like phase separation, which is concomitant with a transition from small complexes to huge polymeric assemblies, as the concentration increases.

Date: 2012
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DOI: 10.1038/nature10879

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