IDH mutation impairs histone demethylation and results in a block to cell differentiation

Chao Lu, Patrick S. Ward, Gurpreet S. Kapoor, Dan Rohle, Sevin Turcan, Omar Abdel-Wahab, Christopher R. Edwards, Raya Khanin, Maria E. Figueroa, Ari Melnick, Kathryn E. Wellen, Donald M. O’Rourke, Shelley L. Berger, Timothy A. Chan, Ross L. Levine, Ingo K. Mellinghoff and Craig B. Thompson ()
Additional contact information
Chao Lu: Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center
Patrick S. Ward: Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center
Gurpreet S. Kapoor: Perelman School of Medicine, University of Pennsylvania
Dan Rohle: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
Sevin Turcan: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
Omar Abdel-Wahab: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
Christopher R. Edwards: Perelman School of Medicine, University of Pennsylvania
Raya Khanin: Bioinformatics Core, Memorial Sloan-Kettering Cancer Center
Maria E. Figueroa: Weill Cornell Medical College
Ari Melnick: Weill Cornell Medical College
Kathryn E. Wellen: Perelman School of Medicine, University of Pennsylvania
Donald M. O’Rourke: Perelman School of Medicine, University of Pennsylvania
Shelley L. Berger: Perelman School of Medicine, University of Pennsylvania
Timothy A. Chan: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
Ross L. Levine: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
Ingo K. Mellinghoff: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
Craig B. Thompson: Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center

Nature, 2012, vol. 483, issue 7390, 474-478

Abstract: Cancer-associated IDH mutants that produce 2-hydroxyglutarate are shown to prevent the histone demethylation that is required for lineage-specific progenitor cells to differentiate into terminally differentiated cells.

Date: 2012
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DOI: 10.1038/nature10860

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