IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

Sevin Turcan, Daniel Rohle, Anuj Goenka, Logan A. Walsh, Fang Fang, Emrullah Yilmaz, Carl Campos, Armida W. M. Fabius, Chao Lu, Patrick S. Ward, Craig B. Thompson, Andrew Kaufman, Olga Guryanova, Ross Levine, Adriana Heguy, Agnes Viale, Luc G. T. Morris, Jason T. Huse, Ingo K. Mellinghoff () and Timothy A. Chan ()
Additional contact information
Sevin Turcan: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
Daniel Rohle: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
Anuj Goenka: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
Logan A. Walsh: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
Fang Fang: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
Emrullah Yilmaz: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
Carl Campos: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
Armida W. M. Fabius: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
Chao Lu: Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center
Patrick S. Ward: Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center
Craig B. Thompson: Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center
Andrew Kaufman: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
Olga Guryanova: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
Ross Levine: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
Adriana Heguy: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
Agnes Viale: Genomics Core, Memorial Sloan-Kettering Cancer Center
Luc G. T. Morris: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
Jason T. Huse: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
Ingo K. Mellinghoff: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
Timothy A. Chan: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center

Nature, 2012, vol. 483, issue 7390, 479-483

Abstract: Mutation of isocitrate dehydrogenase 1 (IDH1) is shown to induce DNA hypermethylation and to remodel the epigenome to resemble that of gliomas with the CpG island methylator phenotype.

Date: 2012
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DOI: 10.1038/nature10866

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