Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodelling

Christoph Reinhardt, Mattias Bergentall, Thomas U. Greiner, Florence Schaffner, Gunnel Östergren-Lundén, Lars C. Petersen, Wolfram Ruf and Fredrik Bäckhed ()
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Christoph Reinhardt: Sahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, University of Gothenburg, 413 45 Gothenburg, Sweden
Mattias Bergentall: Sahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, University of Gothenburg, 413 45 Gothenburg, Sweden
Thomas U. Greiner: Sahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, University of Gothenburg, 413 45 Gothenburg, Sweden
Florence Schaffner: The Scripps Research Institute
Gunnel Östergren-Lundén: Sahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, University of Gothenburg, 413 45 Gothenburg, Sweden
Lars C. Petersen: Haemostasis Biology, Novo Nordisk A/S, DK-2760 Maalov, Denmark
Wolfram Ruf: The Scripps Research Institute
Fredrik Bäckhed: Sahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, University of Gothenburg, 413 45 Gothenburg, Sweden

Nature, 2012, vol. 483, issue 7391, 627-631

Abstract: Colonization of germ-free mice with microbiota promotes vascular growth in the small intestine through a mechanism involving tissue factor, PAR1 and Ang1.

Date: 2012
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DOI: 10.1038/nature10893

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