Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

Jan J. Molenaar (), Jan Koster, Danny A. Zwijnenburg, Peter van Sluis, Linda J. Valentijn, Ida van der Ploeg, Mohamed Hamdi, Johan van Nes, Bart A. Westerman, Jennemiek van Arkel, Marli E. Ebus, Franciska Haneveld, Arjan Lakeman, Linda Schild, Piet Molenaar, Peter Stroeken, Max M. van Noesel, Ingrid Øra, Evan E. Santo, Huib N. Caron, Ellen M. Westerhout and Rogier Versteeg ()
Additional contact information
Jan J. Molenaar: Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Jan Koster: Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Danny A. Zwijnenburg: Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Peter van Sluis: Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Linda J. Valentijn: Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Ida van der Ploeg: Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Mohamed Hamdi: Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Johan van Nes: Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Bart A. Westerman: Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Jennemiek van Arkel: Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Marli E. Ebus: Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Franciska Haneveld: Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Arjan Lakeman: Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Linda Schild: Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Piet Molenaar: Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Peter Stroeken: Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Max M. van Noesel: Erasmus MC-Sophia Children’s Hospital, 3015 GJ Rotterdam, The Netherlands
Ingrid Øra: Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Evan E. Santo: Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Huib N. Caron: Emma Children’s Hospital, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands
Ellen M. Westerhout: Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Rogier Versteeg: Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

Nature, 2012, vol. 483, issue 7391, 589-593

Abstract: Whole-genome sequencing of neuroblastoma, a childhood tumour of the nervous system, shows that chromothripsis (a local shredding of chromosomes) and mutations in genes regulating neurite growth are associated with the most aggressive tumours.

Date: 2012
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DOI: 10.1038/nature10910

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