The mechanism of OTUB1-mediated inhibition of ubiquitination

Reuven Wiener, Xiangbin Zhang, Tao Wang and Cynthia Wolberger ()
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Reuven Wiener: Johns Hopkins University School of Medicine
Xiangbin Zhang: Johns Hopkins University School of Medicine
Tao Wang: Johns Hopkins University School of Medicine
Cynthia Wolberger: Johns Hopkins University School of Medicine

Nature, 2012, vol. 483, issue 7391, 618-622

Abstract: OTUB1 is an atypical deubiquitinating enzyme which prevents ubiquitin attachment and is important in the DNA damage pathway; structural analysis of OTUB1 in complex with an E2 ubiquitin-conjugating enzyme reveals that the ability of OTUB1 to inhibit ubiquitin chain synthesis is regulated by an allosteric feedback mechanism.

Date: 2012
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DOI: 10.1038/nature10911

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