Deregulated MYC expression induces dependence upon AMPK-related kinase 5

Lidan Liu, Jannes Ulbrich, Judith Müller, Torsten Wüstefeld, Lukas Aeberhard, Theresia R. Kress, Nathiya Muthalagu, Lukas Rycak, Ramona Rudalska, Roland Moll, Stefan Kempa, Lars Zender, Martin Eilers () and Daniel J. Murphy ()
Additional contact information
Lidan Liu: Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany
Jannes Ulbrich: Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany
Judith Müller: Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany
Torsten Wüstefeld: Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
Lukas Aeberhard: Max-Delbrück-Center for Molecular Medicine, Berlin Institute for Medical Systems Biology, Robert Rössle Strasse 10, Berlin 13125, Germany
Theresia R. Kress: Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany
Nathiya Muthalagu: Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany
Lukas Rycak: Institute of Molecular Biology and Tumor Research, Emil-Mannkopff-Str. 2, 35037 Marburg, Germany
Ramona Rudalska: Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
Roland Moll: Institute for Pathology, University of Marburg, Baldingerstrasse, 35033 Marburg, Germany
Stefan Kempa: Max-Delbrück-Center for Molecular Medicine, Berlin Institute for Medical Systems Biology, Robert Rössle Strasse 10, Berlin 13125, Germany
Lars Zender: Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
Martin Eilers: Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany
Daniel J. Murphy: Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany

Nature, 2012, vol. 483, issue 7391, 608-612

Abstract: Oncogenic levels of MYC, the deregulation of which is implicated in many human tumours, are shown to establish a dependence on ARK5, offering insights into potential therapeutic strategies.

Date: 2012
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DOI: 10.1038/nature10927

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