A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response

Zhao Chen, Katherine Cheng, Zandra Walton, Yuchuan Wang, Hiromichi Ebi, Takeshi Shimamura, Yan Liu, Tanya Tupper, Jing Ouyang, Jie Li, Peng Gao, Michele S. Woo, Chunxiao Xu, Masahiko Yanagita, Abigail Altabef, Shumei Wang, Charles Lee, Yuji Nakada, Christopher G. Peña, Yanping Sun, Yoko Franchetti, Catherine Yao, Amy Saur, Michael D. Cameron, Mizuki Nishino, D. Neil Hayes, Matthew D. Wilkerson, Patrick J. Roberts, Carrie B. Lee, Nabeel Bardeesy, Mohit Butaney, Lucian R. Chirieac, Daniel B. Costa, David Jackman, Norman E. Sharpless, Diego H. Castrillon, George D. Demetri, Pasi A. Jänne, Pier Paolo Pandolfi, Lewis C. Cantley, Andrew L. Kung (), Jeffrey A. Engelman () and Kwok-Kin Wong ()
Additional contact information
Zhao Chen: Harvard Medical School
Katherine Cheng: Dana-Farber Cancer Institute
Zandra Walton: Dana-Farber Cancer Institute
Yuchuan Wang: Lurie Family Imaging Center, Dana-Farber Cancer Institute
Hiromichi Ebi: Harvard Medical School
Takeshi Shimamura: Oncology Institute, Loyola University Chicago Stritch School of Medicine
Yan Liu: Harvard Medical School
Tanya Tupper: Lurie Family Imaging Center, Dana-Farber Cancer Institute
Jing Ouyang: Dana-Farber Cancer Institute
Jie Li: Center for Survey Statistics & Methodology, Iowa State University
Peng Gao: Dana-Farber Cancer Institute
Michele S. Woo: Dana-Farber Cancer Institute
Chunxiao Xu: Harvard Medical School
Masahiko Yanagita: Dana-Farber Cancer Institute
Abigail Altabef: Dana-Farber Cancer Institute
Shumei Wang: Brigham and Women’s Hospital
Charles Lee: Brigham and Women’s Hospital
Yuji Nakada: UT Southwestern Medical Center
Christopher G. Peña: UT Southwestern Medical Center
Yanping Sun: Lurie Family Imaging Center, Dana-Farber Cancer Institute
Yoko Franchetti: Dana-Farber Cancer Institute, Harvard School of Public Health
Catherine Yao: Dana-Farber Cancer Institute
Amy Saur: Lurie Family Imaging Center, Dana-Farber Cancer Institute
Michael D. Cameron: Translational Research Institute, The Scripps Research Institute
Mizuki Nishino: Dana-Farber Cancer Institute
D. Neil Hayes: The Lineberger Comprehensive Cancer Center, University of North Carolina
Matthew D. Wilkerson: The Lineberger Comprehensive Cancer Center, University of North Carolina
Patrick J. Roberts: The Lineberger Comprehensive Cancer Center, University of North Carolina
Carrie B. Lee: The Lineberger Comprehensive Cancer Center, University of North Carolina
Nabeel Bardeesy: Massachusetts General Hospital Cancer Center
Mohit Butaney: Dana-Farber Cancer Institute
Lucian R. Chirieac: Brigham and Women’s Hospital
Daniel B. Costa: Beth Israel Deaconess Medical Center, Harvard Medical School
David Jackman: Dana-Farber Cancer Institute
Norman E. Sharpless: The Lineberger Comprehensive Cancer Center, University of North Carolina
Diego H. Castrillon: UT Southwestern Medical Center
George D. Demetri: Ludwig Center at Dana-Farber/Harvard Cancer Center, Dana-Farber Cancer Institute
Pasi A. Jänne: Harvard Medical School
Pier Paolo Pandolfi: Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School
Lewis C. Cantley: Harvard Medical School
Andrew L. Kung: Lurie Family Imaging Center, Dana-Farber Cancer Institute
Jeffrey A. Engelman: Harvard Medical School
Kwok-Kin Wong: Harvard Medical School

Nature, 2012, vol. 483, issue 7391, 613-617

Abstract: In parallel with an ongoing human clinical trial, genetically engineered mouse models of lung cancer with different genetic alterations are treated with chemotherapeutic agents; the results have implications for the clinical trial.

Date: 2012
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DOI: 10.1038/nature10937

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