Chromatin-modifying enzymes as modulators of reprogramming

Tamer T. Onder, Nergis Kara, Anne Cherry, Amit U. Sinha, Nan Zhu, Kathrin M. Bernt, Patrick Cahan, B. Ogan Mancarci, Juli Unternaehrer, Piyush B. Gupta, Eric S. Lander, Scott A. Armstrong and George Q. Daley ()
Additional contact information
Tamer T. Onder: Stem Cell Transplantation Program, Manton Center for Orphan Disease Research, Children’s Hospital Boston and Dana Farber Cancer Institute
Nergis Kara: German Cancer Research Center, Heidelberg, 69120, Germany
Anne Cherry: Stem Cell Transplantation Program, Manton Center for Orphan Disease Research, Children’s Hospital Boston and Dana Farber Cancer Institute
Amit U. Sinha: Children’s Hospital, Harvard Medical School
Nan Zhu: Harvard Stem Cell Institute, Cambridge
Kathrin M. Bernt: Harvard Stem Cell Institute, Cambridge
Patrick Cahan: Stem Cell Transplantation Program, Manton Center for Orphan Disease Research, Children’s Hospital Boston and Dana Farber Cancer Institute
B. Ogan Mancarci: Bilkent University
Juli Unternaehrer: Stem Cell Transplantation Program, Manton Center for Orphan Disease Research, Children’s Hospital Boston and Dana Farber Cancer Institute
Piyush B. Gupta: Massachusetts Institute of Technology
Eric S. Lander: Massachusetts Institute of Technology
Scott A. Armstrong: Harvard Stem Cell Institute, Cambridge
George Q. Daley: Stem Cell Transplantation Program, Manton Center for Orphan Disease Research, Children’s Hospital Boston and Dana Farber Cancer Institute

Nature, 2012, vol. 483, issue 7391, 598-602

Abstract: Inhibition of DOT1L, the H3K79 histone methyltransferase, increases cell reprogramming and substituted for KLF4 and c-Myc, showing that chromatin-modifying enzymes act not only as facilitators but also as barriers to reprogramming.

Date: 2012
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DOI: 10.1038/nature10953

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