The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

Jordi Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehár, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy, Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jané-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guoying K. Yu, Jianjun Yu, Peter Aspesi, Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura MacConaill, Wendy Winckler, Michael Reich, Nanxin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Meyerson, Todd R. Golub, Michael P. Morrissey, William R. Sellers, Robert Schlegel () and Levi A. Garraway ()
Additional contact information
Jordi Barretina: The Broad Institute of Harvard and MIT
Giordano Caponigro: Novartis Institutes for Biomedical Research
Nicolas Stransky: The Broad Institute of Harvard and MIT
Kavitha Venkatesan: Novartis Institutes for Biomedical Research
Adam A. Margolin: The Broad Institute of Harvard and MIT
Sungjoon Kim: Genomics Institute of the Novartis Research Foundation
Christopher J. Wilson: Novartis Institutes for Biomedical Research
Joseph Lehár: Novartis Institutes for Biomedical Research
Gregory V. Kryukov: The Broad Institute of Harvard and MIT
Dmitriy Sonkin: Novartis Institutes for Biomedical Research
Anupama Reddy: Novartis Institutes for Biomedical Research
Manway Liu: Novartis Institutes for Biomedical Research
Lauren Murray: The Broad Institute of Harvard and MIT
Michael F. Berger: The Broad Institute of Harvard and MIT
John E. Monahan: Novartis Institutes for Biomedical Research
Paula Morais: The Broad Institute of Harvard and MIT
Jodi Meltzer: Novartis Institutes for Biomedical Research
Adam Korejwa: The Broad Institute of Harvard and MIT
Judit Jané-Valbuena: The Broad Institute of Harvard and MIT
Felipa A. Mapa: Novartis Institutes for Biomedical Research
Joseph Thibault: Genomics Institute of the Novartis Research Foundation
Eva Bric-Furlong: Novartis Institutes for Biomedical Research
Pichai Raman: Novartis Institutes for Biomedical Research
Aaron Shipway: Genomics Institute of the Novartis Research Foundation
Ingo H. Engels: Genomics Institute of the Novartis Research Foundation
Jill Cheng: Novartis Institutes for Biomedical Research
Guoying K. Yu: Novartis Institutes for Biomedical Research
Jianjun Yu: Novartis Institutes for Biomedical Research
Peter Aspesi: Novartis Institutes for Biomedical Research
Melanie de Silva: Novartis Institutes for Biomedical Research
Kalpana Jagtap: Novartis Institutes for Biomedical Research
Michael D. Jones: Novartis Institutes for Biomedical Research
Li Wang: Novartis Institutes for Biomedical Research
Charles Hatton: Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Harvard Medical School
Emanuele Palescandolo: Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Harvard Medical School
Supriya Gupta: The Broad Institute of Harvard and MIT
Scott Mahan: The Broad Institute of Harvard and MIT
Carrie Sougnez: The Broad Institute of Harvard and MIT
Robert C. Onofrio: The Broad Institute of Harvard and MIT
Ted Liefeld: The Broad Institute of Harvard and MIT
Laura MacConaill: Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Harvard Medical School
Wendy Winckler: The Broad Institute of Harvard and MIT
Michael Reich: The Broad Institute of Harvard and MIT
Nanxin Li: Genomics Institute of the Novartis Research Foundation
Jill P. Mesirov: The Broad Institute of Harvard and MIT
Stacey B. Gabriel: The Broad Institute of Harvard and MIT
Gad Getz: The Broad Institute of Harvard and MIT
Kristin Ardlie: The Broad Institute of Harvard and MIT
Vivien Chan: Novartis Institutes for Biomedical Research
Vic E. Myer: Novartis Institutes for Biomedical Research
Barbara L. Weber: Novartis Institutes for Biomedical Research
Jeff Porter: Novartis Institutes for Biomedical Research
Markus Warmuth: Novartis Institutes for Biomedical Research
Peter Finan: Novartis Institutes for Biomedical Research
Jennifer L. Harris: Genomics Institute of the Novartis Research Foundation
Matthew Meyerson: The Broad Institute of Harvard and MIT
Todd R. Golub: The Broad Institute of Harvard and MIT
Michael P. Morrissey: Novartis Institutes for Biomedical Research
William R. Sellers: Novartis Institutes for Biomedical Research
Robert Schlegel: Novartis Institutes for Biomedical Research
Levi A. Garraway: The Broad Institute of Harvard and MIT

Nature, 2012, vol. 483, issue 7391, 603-607

Abstract: The Cancer Cell Line Encyclopedia presents the first results from a large-scale screen of some 947 cancer cell lines with 24 anticancer drugs, with the aim of identifying specific genomic alterations and gene expression profiles associated with selective sensitivity or resistance to potential therapeutic agents.

Date: 2012
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DOI: 10.1038/nature11003

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