Wild-type microglia arrest pathology in a mouse model of Rett syndrome

Noël C. Derecki, James C. Cronk, Zhenjie Lu, Eric Xu, Stephen B. G. Abbott, Patrice G. Guyenet and Jonathan Kipnis ()
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Noël C. Derecki: School of Medicine, University of Virginia
James C. Cronk: School of Medicine, University of Virginia
Zhenjie Lu: School of Medicine, University of Virginia
Eric Xu: School of Medicine, University of Virginia
Stephen B. G. Abbott: School of Medicine, University of Virginia
Patrice G. Guyenet: School of Medicine, University of Virginia
Jonathan Kipnis: School of Medicine, University of Virginia

Nature, 2012, vol. 484, issue 7392, 105-109

Abstract: Transplanting bone marrow from wild-type mice into MECP2-lacking mice results in wild-type microglial engraftment, extends lifespan and reduces symptoms of disease such as breathing and locomotor abnormalities, implicating microglia in the pathophysiology of Rett syndrome.

Date: 2012
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DOI: 10.1038/nature10907

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