Choice-specific sequences in parietal cortex during a virtual-navigation decision task

Christopher D. Harvey (), Philip Coen and David W. Tank ()
Additional contact information
Christopher D. Harvey: Princeton Neuroscience Institute, Princeton University
Philip Coen: Princeton Neuroscience Institute, Princeton University
David W. Tank: Princeton Neuroscience Institute, Princeton University

Nature, 2012, vol. 484, issue 7392, 62-68

Abstract: Abstract The posterior parietal cortex (PPC) has an important role in many cognitive behaviours; however, the neural circuit dynamics underlying PPC function are not well understood. Here we optically imaged the spatial and temporal activity patterns of neuronal populations in mice performing a PPC-dependent task that combined a perceptual decision and memory-guided navigation in a virtual environment. Individual neurons had transient activation staggered relative to one another in time, forming a sequence of neuronal activation spanning the entire length of a task trial. Distinct sequences of neurons were triggered on trials with opposite behavioural choices and defined divergent, choice-specific trajectories through a state space of neuronal population activity. Cells participating in the different sequences and at distinct time points in the task were anatomically intermixed over microcircuit length scales (

Date: 2012
References: Add references at CitEc
Citations: View citations in EconPapers (15)

Downloads: (external link)
https://www.nature.com/articles/nature10918 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:484:y:2012:i:7392:d:10.1038_nature10918

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature10918

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().