Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy

Yujie Cui, Wei Wang, Ningzheng Dong, Jinglei Lou, Dinesh Kumar Srinivasan, Weiwei Cheng, Xiaoyi Huang, Meng Liu, Chaodong Fang, Jianhao Peng, Shenghan Chen, Shannon Wu, Zhenzhen Liu, Liang Dong, Yiqing Zhou and Qingyu Wu ()
Additional contact information
Yujie Cui: Molecular Cardiology, Nephrology and Hypertension, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
Wei Wang: Molecular Cardiology, Nephrology and Hypertension, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
Ningzheng Dong: Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, 199 Ren Ai Road, Suzhou 215123, China
Jinglei Lou: Molecular Cardiology, Nephrology and Hypertension, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
Dinesh Kumar Srinivasan: Molecular Cardiology, Nephrology and Hypertension, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
Weiwei Cheng: The International Peace Maternity and Child Health Hospital, Shanghai Jiaotong University School of Medicine, 910 Hengshan Road, Shanghai 200030, China
Xiaoyi Huang: The International Peace Maternity and Child Health Hospital, Shanghai Jiaotong University School of Medicine, 910 Hengshan Road, Shanghai 200030, China
Meng Liu: Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, 199 Ren Ai Road, Suzhou 215123, China
Chaodong Fang: Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, 199 Ren Ai Road, Suzhou 215123, China
Jianhao Peng: Molecular Cardiology, Nephrology and Hypertension, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
Shenghan Chen: Molecular Cardiology, Nephrology and Hypertension, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
Shannon Wu: Molecular Cardiology, Nephrology and Hypertension, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
Zhenzhen Liu: Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, 199 Ren Ai Road, Suzhou 215123, China
Liang Dong: Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, 199 Ren Ai Road, Suzhou 215123, China
Yiqing Zhou: Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, 199 Ren Ai Road, Suzhou 215123, China
Qingyu Wu: Molecular Cardiology, Nephrology and Hypertension, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA

Nature, 2012, vol. 484, issue 7393, 246-250

Abstract: Pregnant corin- or ANP-deficient mice have impaired trophoblast invasion and uterine spiral artery remodelling, and patients with pre-eclampsia have lower uterine corin messenger RNA and protein levels than normal pregnancies, suggesting that defects in corin and ANP function may contribute to pre-eclampsia.

Date: 2012
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DOI: 10.1038/nature10897

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