A new understanding of the decoding principle on the ribosome

Natalia Demeshkina, Lasse Jenner, Eric Westhof, Marat Yusupov () and Gulnara Yusupova ()
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Natalia Demeshkina: Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch 67400, France; CNRS, UMR7104, Illkirch 67400, France; INSERM, U964, Illkirch 67400, France; Université de Strasbourg
Lasse Jenner: Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch 67400, France; CNRS, UMR7104, Illkirch 67400, France; INSERM, U964, Illkirch 67400, France; Université de Strasbourg
Eric Westhof: Architecture et Réactivité de l’ARN, Université de Strasbourg, Institut de Biologie Moléculaire et Cellulaire, CNRS, Strasbourg 67084, France
Marat Yusupov: Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch 67400, France; CNRS, UMR7104, Illkirch 67400, France; INSERM, U964, Illkirch 67400, France; Université de Strasbourg
Gulnara Yusupova: Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch 67400, France; CNRS, UMR7104, Illkirch 67400, France; INSERM, U964, Illkirch 67400, France; Université de Strasbourg

Nature, 2012, vol. 484, issue 7393, 256-259

Abstract: An integrated mechanism for decoding is proposed, based on six X-ray structures of the 70S ribosome determined at 3.1–3.4 Å resolution, modelling cognate or near-cognate states of the decoding centre at the proofreading step.

Date: 2012
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DOI: 10.1038/nature10913

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