Telomerase RNA biogenesis involves sequential binding by Sm and Lsm complexes

Wen Tang, Ram Kannan, Marco Blanchette and Peter Baumann ()
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Wen Tang: Howard Hughes Medical Institute
Ram Kannan: Howard Hughes Medical Institute
Marco Blanchette: Stowers Institute for Medical Research
Peter Baumann: Howard Hughes Medical Institute

Nature, 2012, vol. 484, issue 7393, 260-264

Abstract: Two complexes of RNA-binding proteins, Sm and Lsm2–8, act sequentially on telomerase RNA during its biogenesis: the Sm ring promotes 3′-cleavage and facilitates hypermethylation of the 5′-cap, whereas the Lsm2–8 complex aids binding of the telomerase catalytic subunit and prevents degradation of the RNA.

Date: 2012
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DOI: 10.1038/nature10924

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