Genome-wide protein–DNA binding dynamics suggest a molecular clutch for transcription factor function

Colin R. Lickwar, Florian Mueller, Sean E. Hanlon, James G. McNally and Jason D. Lieb ()
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Colin R. Lickwar: Carolina Center for the Genome Sciences, Curriculum in Genetics and Molecular Biology, and Lineberger Comprehensive Cancer Center, CB 3280, 408 Fordham Hall, University of North Carolina at Chapel Hill
Florian Mueller: LRBGE-National Cancer Institute, The National Institutes of Health, 41 Library Drive, Bethesda, Maryland 20892, USA
Sean E. Hanlon: Carolina Center for the Genome Sciences, Curriculum in Genetics and Molecular Biology, and Lineberger Comprehensive Cancer Center, CB 3280, 408 Fordham Hall, University of North Carolina at Chapel Hill
James G. McNally: LRBGE-National Cancer Institute, The National Institutes of Health, 41 Library Drive, Bethesda, Maryland 20892, USA
Jason D. Lieb: Carolina Center for the Genome Sciences, Curriculum in Genetics and Molecular Biology, and Lineberger Comprehensive Cancer Center, CB 3280, 408 Fordham Hall, University of North Carolina at Chapel Hill

Nature, 2012, vol. 484, issue 7393, 251-255

Abstract: Competition ChIP with a sequence-specific S. cerevisiae transcription factor, Rap1, reveals that long Rap1 residence is coupled to transcriptional activation, whereas fast binding turnover is linked to low transcriptional output, suggesting that DNA-binding events that appear identical by conventional ChIP may have different underlying modes of interaction, leading to opposing functional outcomes.

Date: 2012
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DOI: 10.1038/nature10985

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