DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation

Pierre Close, Philip East, A. Barbara Dirac-Svejstrup, Holger Hartmann, Mark Heron, Sarah Maslen, Alain Chariot, Johannes Söding, Mark Skehel and Jesper Q. Svejstrup ()
Additional contact information
Pierre Close: Mechanisms of Transcription Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms EN6 3LD, UK
Philip East: Bioinformatics & Biostatistics Group, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
A. Barbara Dirac-Svejstrup: Mechanisms of Transcription Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms EN6 3LD, UK
Holger Hartmann: Gene Center and Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany
Mark Heron: Gene Center and Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany
Sarah Maslen: Protein Analysis and Proteomics Laboratory, Clare Hall Laboratories, Cancer Research UK, London Research Institute, South Mimms EN6 3LD, UK
Alain Chariot: Unit of Medical Chemistry, GIGA-Signal Transduction, GIGA-R, University of Liege, CHU, Sart-Tilman, 4000 Liege, Belgium
Johannes Söding: Gene Center and Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany
Mark Skehel: Protein Analysis and Proteomics Laboratory, Clare Hall Laboratories, Cancer Research UK, London Research Institute, South Mimms EN6 3LD, UK
Jesper Q. Svejstrup: Mechanisms of Transcription Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms EN6 3LD, UK

Nature, 2012, vol. 484, issue 7394, 386-389

Abstract: Characterization of the human interactome of chromatin-associated messenger ribonucleoprotein particles identifies DBC1 and a new protein (ZIRD) as subunits of a protein complex (DBIRD) that binds directly to RNAPII, regulates alternative splicing of exons embedded in (A + T)-rich DNA, and whose depletion results in region-specific decreases in transcript elongation.

Date: 2012
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DOI: 10.1038/nature10925

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