Hsp72 preserves muscle function and slows progression of severe muscular dystrophy

Stefan M. Gehrig, Chris van der Poel, Timothy A. Sayer, Jonathan D. Schertzer, Darren C. Henstridge, Jarrod E. Church, Severine Lamon, Aaron P. Russell, Kay E. Davies, Mark A. Febbraio and Gordon S. Lynch ()
Additional contact information
Stefan M. Gehrig: Basic and Clinical Myology Laboratory, University of Melbourne
Chris van der Poel: Basic and Clinical Myology Laboratory, University of Melbourne
Timothy A. Sayer: Basic and Clinical Myology Laboratory, University of Melbourne
Jonathan D. Schertzer: Basic and Clinical Myology Laboratory, University of Melbourne
Darren C. Henstridge: Cellular and Molecular Metabolism Laboratory, Baker-IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Victoria, 8008, Australia
Jarrod E. Church: Basic and Clinical Myology Laboratory, University of Melbourne
Severine Lamon: Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, 3125, Australia
Aaron P. Russell: Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, 3125, Australia
Kay E. Davies: MRC Functional Genomics Unit, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Mark A. Febbraio: Cellular and Molecular Metabolism Laboratory, Baker-IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Victoria, 8008, Australia
Gordon S. Lynch: Basic and Clinical Myology Laboratory, University of Melbourne

Nature, 2012, vol. 484, issue 7394, 394-398

Abstract: Increasing the expression of intramuscular heat shock protein 72 preserves muscle strength and ameliorates the dystrophic pathology in two mouse models of muscular dystrophy, suggesting a promising way forward for the treatment of muscular dystrophy.

Date: 2012
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DOI: 10.1038/nature10980

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