IFITM3 restricts the morbidity and mortality associated with influenza

Aaron R. Everitt, Simon Clare, Thomas Pertel, Sinu P. John, Rachael S. Wash, Sarah E. Smith, Christopher R. Chin, Eric M. Feeley, Jennifer S. Sims, David J. Adams, Helen M. Wise, Leanne Kane, David Goulding, Paul Digard, Verneri Anttila, J. Kenneth Baillie, Tim S. Walsh, David A. Hume, Aarno Palotie, Yali Xue, Vincenza Colonna, Chris Tyler-Smith, Jake Dunning, Stephen B. Gordon, Rosalind L. Smyth, Peter J. Openshaw, Gordon Dougan, Abraham L. Brass () and Paul Kellam ()
Additional contact information
Aaron R. Everitt: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
Simon Clare: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
Thomas Pertel: Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University
Sinu P. John: Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University
Rachael S. Wash: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
Sarah E. Smith: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
Christopher R. Chin: Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University
Eric M. Feeley: Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University
Jennifer S. Sims: Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University
David J. Adams: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
Helen M. Wise: Divison of Virology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
Leanne Kane: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
David Goulding: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
Paul Digard: Divison of Virology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
Verneri Anttila: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
J. Kenneth Baillie: The Roslin Institute, University of Edinburgh, Roslin EH25 9RG, UK
Tim S. Walsh: University of Edinburgh, Edinburgh EH16 4TJ, UK
David A. Hume: The Roslin Institute, University of Edinburgh, Roslin EH25 9RG, UK
Aarno Palotie: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
Yali Xue: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
Vincenza Colonna: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
Chris Tyler-Smith: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
Jake Dunning: Centre for Respiratory Infection, National Heart and Lung Institute, St Mary’s Campus, Imperial College London, W2 1PG, UK
Stephen B. Gordon: Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
Rosalind L. Smyth: Institute of Translational Medicine, University of Liverpool, Alder Hey Children’s Hospital, Liverpool L12 2AP, UK
Peter J. Openshaw: Centre for Respiratory Infection, National Heart and Lung Institute, St Mary’s Campus, Imperial College London, W2 1PG, UK
Gordon Dougan: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
Abraham L. Brass: Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University
Paul Kellam: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK

Nature, 2012, vol. 484, issue 7395, 519-523

Abstract: Interferon-inducible transmembrane (IFITM) protein 3 is shown to be an innate defence mechanism against viral infection in vivo; furthermore, a subset of the patients hospitalized during the H1N1 2009 pandemic carried a variant form of the IFITM3 gene.

Date: 2012
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DOI: 10.1038/nature10921

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