Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β

Christina E. Zielinski (), Federico Mele, Dominik Aschenbrenner, David Jarrossay, Francesca Ronchi, Marco Gattorno, Silvia Monticelli, Antonio Lanzavecchia and Federica Sallusto ()
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Christina E. Zielinski: Institute for Research in Biomedicine
Federico Mele: Institute for Research in Biomedicine
Dominik Aschenbrenner: Institute for Research in Biomedicine
David Jarrossay: Institute for Research in Biomedicine
Francesca Ronchi: Institute for Research in Biomedicine
Marco Gattorno: “G. Gaslini” Scientific Institute, Largo G. Gaslini 5, 16147, Genova, Italy
Silvia Monticelli: Institute for Research in Biomedicine
Antonio Lanzavecchia: Institute for Research in Biomedicine
Federica Sallusto: Institute for Research in Biomedicine

Nature, 2012, vol. 484, issue 7395, 514-518

Abstract: Infection with Candida albicans and Staphylococcus aureus gives rise to TH17 cells with different properties; microbe-induced T-cell differentiation is shown here to depend on the balance between polarizing cytokines rather than absolute amounts.

Date: 2012
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DOI: 10.1038/nature10957

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