An inverse relationship to germline transcription defines centromeric chromatin in C. elegans

Reto Gassmann, Andreas Rechtsteiner, Karen W. Yuen, Andrew Muroyama, Thea Egelhofer, Laura Gaydos, Francie Barron, Paul Maddox, Anthony Essex, Joost Monen, Sevinc Ercan, Jason D. Lieb, Karen Oegema, Susan Strome () and Arshad Desai ()
Additional contact information
Reto Gassmann: Ludwig Institute for Cancer Research and Department of Cellular & Molecular Medicine University of California San Diego
Andreas Rechtsteiner: University of California Santa Cruz
Karen W. Yuen: Ludwig Institute for Cancer Research and Department of Cellular & Molecular Medicine University of California San Diego
Andrew Muroyama: Ludwig Institute for Cancer Research and Department of Cellular & Molecular Medicine University of California San Diego
Thea Egelhofer: University of California Santa Cruz
Laura Gaydos: University of California Santa Cruz
Francie Barron: Ludwig Institute for Cancer Research and Department of Cellular & Molecular Medicine University of California San Diego
Paul Maddox: Ludwig Institute for Cancer Research and Department of Cellular & Molecular Medicine University of California San Diego
Anthony Essex: Ludwig Institute for Cancer Research and Department of Cellular & Molecular Medicine University of California San Diego
Joost Monen: Ludwig Institute for Cancer Research and Department of Cellular & Molecular Medicine University of California San Diego
Sevinc Ercan: Carolina Center for Genome Sciences and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Jason D. Lieb: Carolina Center for Genome Sciences and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Karen Oegema: Ludwig Institute for Cancer Research and Department of Cellular & Molecular Medicine University of California San Diego
Susan Strome: University of California Santa Cruz
Arshad Desai: Ludwig Institute for Cancer Research and Department of Cellular & Molecular Medicine University of California San Diego

Nature, 2012, vol. 484, issue 7395, 534-537

Abstract: Centromere identity is thought to be epigenetically propagated by stable inheritance of nucleosomes containing the histone variant CENP-A; the authors propose a different model here in which germline transcription defines the genomic regions that exclude CENP-A incorporation during embryogenesis in the holocentric worm Caenorhabditis elegans.

Date: 2012
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DOI: 10.1038/nature10973

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