Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’

Aron M. Levin, Darren L. Bates, Aaron M. Ring, Carsten Krieg, Jack T. Lin, Leon Su, Ignacio Moraga, Miro E. Raeber, Gregory R. Bowman, Paul Novick, Vijay S. Pande, C. Garrison Fathman, Onur Boyman () and K. Christopher Garcia ()
Additional contact information
Aron M. Levin: Howard Hughes Medical Institute, Stanford University School of Medicine
Darren L. Bates: Stanford University School of Medicine
Aaron M. Ring: Stanford University School of Medicine
Carsten Krieg: Laboratory of Applied Immunobiology, University of Zurich, Zurich CH-8006, Switzerland
Jack T. Lin: Stanford University School of Medicine, Stanford, California 94305, USA
Leon Su: Stanford University School of Medicine, Stanford, California 94305, USA
Ignacio Moraga: Stanford University School of Medicine
Miro E. Raeber: Laboratory of Applied Immunobiology, University of Zurich, Zurich CH-8006, Switzerland
Gregory R. Bowman: Stanford University
Paul Novick: Stanford University
Vijay S. Pande: Stanford University
C. Garrison Fathman: Stanford University School of Medicine, Stanford, California 94305, USA
Onur Boyman: Laboratory of Applied Immunobiology, University of Zurich, Zurich CH-8006, Switzerland
K. Christopher Garcia: Howard Hughes Medical Institute, Stanford University School of Medicine

Nature, 2012, vol. 484, issue 7395, 529-533

Abstract: Although IL-2 has been studied for its immune-stimulating activity against metastatic cancer, its side effects have limited its clinical use; here, an engineered IL-2 ‘superkine’ is shown to have increased activity, particularly in inducing antitumour T cells, but fewer side effects.

Date: 2012
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DOI: 10.1038/nature10975

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