Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding

Eliana Marinari, Aida Mehonic, Scott Curran, Jonathan Gale, Thomas Duke and Buzz Baum ()
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Eliana Marinari: Medical Research Council Laboratory of Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
Aida Mehonic: University College London, Gower Street, London WC1E 6BT, UK
Scott Curran: Medical Research Council Laboratory of Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
Jonathan Gale: UCL Ear Institute, University College London, 332 Gray’s Inn Road, London WC1X 8EE, UK
Thomas Duke: University College London, Gower Street, London WC1E 6BT, UK
Buzz Baum: Medical Research Council Laboratory of Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK

Nature, 2012, vol. 484, issue 7395, 542-545

Abstract: To maintain homeostasis in epithelial cell layers in Drosophila, cell overcrowding causes a proportion of cells to undergo a loss of cell adhesive junctions and be squeezed out by neighbouring cells.

Date: 2012
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DOI: 10.1038/nature10984

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