Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia

George T. Eisenhoffer, Patrick D. Loftus, Masaaki Yoshigi, Hideo Otsuna, Chi-Bin Chien, Paul A. Morcos and Jody Rosenblatt ()
Additional contact information
George T. Eisenhoffer: Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope Drive, Salt Lake City, Utah 84112, USA
Patrick D. Loftus: Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope Drive, Salt Lake City, Utah 84112, USA
Masaaki Yoshigi: University of Utah, 295 Chipeta Way RM 2S010, Salt Lake City, Utah 84108, USA
Hideo Otsuna: University of Utah, 401 MREB, 20N 1900E, Salt Lake City, Utah 84132, USA
Chi-Bin Chien: University of Utah, 401 MREB, 20N 1900E, Salt Lake City, Utah 84132, USA
Paul A. Morcos: Gene Tools, LLC, 1001 Summerton Way, Philmath, Oregon 97370, USA
Jody Rosenblatt: Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope Drive, Salt Lake City, Utah 84112, USA

Nature, 2012, vol. 484, issue 7395, 546-549

Abstract: Here it is shown that epithelia extrude live but not dying cells at sites of high strain, elucidating a mechanism for maintaining homeostatic cell numbers.

Date: 2012
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/nature10999 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:484:y:2012:i:7395:d:10.1038_nature10999

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature10999

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().