Infection regulates pro-resolving mediators that lower antibiotic requirements

Nan Chiang, Gabrielle Fredman, Fredrik Bäckhed, Sungwhan F. Oh, Thad Vickery, Birgitta A. Schmidt and Charles N. Serhan ()
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Nan Chiang: Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women’s Hospital and Harvard Medical School
Gabrielle Fredman: Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women’s Hospital and Harvard Medical School
Fredrik Bäckhed: Sahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, University of Gothenburg, SE-413 45 Gothenburg, Sweden
Sungwhan F. Oh: Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women’s Hospital and Harvard Medical School
Thad Vickery: Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women’s Hospital and Harvard Medical School
Birgitta A. Schmidt: Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women’s Hospital and Harvard Medical School
Charles N. Serhan: Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women’s Hospital and Harvard Medical School

Nature, 2012, vol. 484, issue 7395, 524-528

Abstract: Resolvins and protectins are anti-inflammatory and pro-resolving lipid mediators that are shown to resolve infections, and their administration lowers required doses of antibiotics and shortens infections.

Date: 2012
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DOI: 10.1038/nature11042

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