Evidence of non-random mutation rates suggests an evolutionary risk management strategy

Iñigo Martincorena (), Aswin S. N. Seshasayee and Nicholas M. Luscombe ()
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Iñigo Martincorena: EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK
Aswin S. N. Seshasayee: EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK
Nicholas M. Luscombe: EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK

Nature, 2012, vol. 485, issue 7396, 95-98

Abstract: The local mutation rate in Escherichia coli has evolved to reduce the risk of deleterious mutations, leading to a non-random occurrence of mutations and suggesting that DNA protection and repair mechanisms preferentially target more important genes.

Date: 2012
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DOI: 10.1038/nature10995

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