Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

Han Cho, Xuan Zhao, Megumi Hatori, Ruth T. Yu, Grant D. Barish, Michael T. Lam, Ling-Wa Chong, Luciano DiTacchio, Annette R. Atkins, Christopher K. Glass, Christopher Liddle, Johan Auwerx, Michael Downes, Satchidananda Panda and Ronald M. Evans ()
Additional contact information
Han Cho: Gene Expression Laboratory, Salk Institute for Biological Studies
Xuan Zhao: Gene Expression Laboratory, Salk Institute for Biological Studies
Megumi Hatori: Regulatory Biology Laboratory, Salk Institute for Biological Studies
Ruth T. Yu: Gene Expression Laboratory, Salk Institute for Biological Studies
Grant D. Barish: Gene Expression Laboratory, Salk Institute for Biological Studies
Michael T. Lam: School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA
Ling-Wa Chong: Gene Expression Laboratory, Salk Institute for Biological Studies
Luciano DiTacchio: Regulatory Biology Laboratory, Salk Institute for Biological Studies
Annette R. Atkins: Gene Expression Laboratory, Salk Institute for Biological Studies
Christopher K. Glass: School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA
Christopher Liddle: The Storr Liver Unit, Westmead Millennium Institute and University of Sydney, Westmead Hospital
Johan Auwerx: Ecole Polytechnique Fédérale in Lausanne CH-1015
Michael Downes: Gene Expression Laboratory, Salk Institute for Biological Studies
Satchidananda Panda: Regulatory Biology Laboratory, Salk Institute for Biological Studies
Ronald M. Evans: Gene Expression Laboratory, Salk Institute for Biological Studies

Nature, 2012, vol. 485, issue 7396, 123-127

Abstract: The nuclear receptors REV-ERB-α and REV-ERB-β are indispensible for the coordination of circadian rhythm and metabolism; mice without these nuclear receptors show disrupted circadian expression of core circadian clock and lipid homeostatic gene networks.

Date: 2012
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DOI: 10.1038/nature11048

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