A unifying model for mTORC1-mediated regulation of mRNA translation

Carson C. Thoreen, Lynne Chantranupong, Heather R. Keys, Tim Wang, Nathanael S. Gray () and David M. Sabatini ()
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Carson C. Thoreen: Dana Farber Cancer Institute, 250 Longwood Avenue, Boston, Massachusetts 02115, USA
Lynne Chantranupong: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Heather R. Keys: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Tim Wang: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Nathanael S. Gray: Dana Farber Cancer Institute, 250 Longwood Avenue, Boston, Massachusetts 02115, USA
David M. Sabatini: Whitehead Institute for Biomedical Research, Nine Cambridge Center

Nature, 2012, vol. 485, issue 7396, 109-113

Abstract: mTORC1 is shown to regulate a translational program that requires the rapamycin-resistant 4E-BP family of translational repressors and consists almost entirely of mRNAs containing 5′ terminal oligopyrimidine or related motifs.

Date: 2012
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DOI: 10.1038/nature11083

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