Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

Takafumi Oka, Shungo Hikoso, Osamu Yamaguchi, Manabu Taneike, Toshihiro Takeda, Takahito Tamai, Jota Oyabu, Tomokazu Murakawa, Hiroyuki Nakayama, Kazuhiko Nishida, Shizuo Akira, Akitsugu Yamamoto, Issei Komuro and Kinya Otsu ()
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Takafumi Oka: Osaka University Graduate School of Medicine
Shungo Hikoso: Osaka University Graduate School of Medicine
Osamu Yamaguchi: Osaka University Graduate School of Medicine
Manabu Taneike: Osaka University Graduate School of Medicine
Toshihiro Takeda: Osaka University Graduate School of Medicine
Takahito Tamai: Osaka University Graduate School of Medicine
Jota Oyabu: Osaka University Graduate School of Medicine
Tomokazu Murakawa: Osaka University Graduate School of Medicine
Hiroyuki Nakayama: Graduate School of Pharmaceutical Sciences, Osaka University
Kazuhiko Nishida: Osaka University Graduate School of Medicine
Shizuo Akira: Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University
Akitsugu Yamamoto: Faculty of Bioscience, Nagahama Institute of Bio-Science and Technology
Issei Komuro: Osaka University Graduate School of Medicine
Kinya Otsu: Osaka University Graduate School of Medicine

Nature, 2012, vol. 485, issue 7397, 251-255

Abstract: Mitochondrial DNA escaping from the autophagy pathway can trigger inflammation through Toll-like receptor (TLR) 9, leading to abnormalities in cardiac structure and function, and increased mortality.

Date: 2012
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DOI: 10.1038/nature10992

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